RAS Pathway DepMap Correlation Network Explorer

Select input cell type and font sizes

Choose a cell type to construct the network of the most critical RAS pathway genes as formed functional modules and Good Paired Mutual Top Correlated (GPMTC) genes

Choose a new cell type to update current network with new cell type-based relationships

Layout

Font size of nodes

Font size of title

Undo last network operation

This reverts the network to the state before the last Add / Subset / Delete / Expand operation.

Add genes into or subset current network(tips: if do both, first subset and then add genes)

Enter genes(separated by space) to add into the network

Make subnetwork using exact input genes shown in the current network instead of all functional module and/or GPMTC genes of the current network

Enter a subset of genes(separated by space) in the network to make a subnetwork

Find and add top bridge gene(s) from Ras Pathway or as GEFs between each pair of input seed genes (as the best correlated gene(s) for each pair)

Enter no more than 20 seed genes from the current network (separated by space) to find the top bridge gene(s) for each pair of the seed genes

Number of top bridge genes to find

Delete genes from network(tips: use gene symbol shown in the network)

Delete gene from dropdown (just select a gene and no need to click on Delete Button):

Enter a subset of genes (separated by space) to be deleted from the network

Expand network by functional module, GPMTC by default and top correlated genes as defined below

# of top positively correlated genes to be added

# of top negatively correlated genes to be added

Only use top correlated RAS pathway or GEF genes (as default if checked box) to expand the network (use genome-wide genes if unchecked box)

Use a subset of genes (if checked box) instead of the full network (as default if unchecked box)

Enter subset of genes (separated by space and exactly gene names shown in the current network,e.g., DOCK5.gef not just DOCK5) to expand from:

Save/Load gene list and relations of the network (Note: be aware the cell type used for new network is the last one used)

Save genes and relations to a .csv file

Browse and only load saved genes and relations (in a .csv file) of the same cell type to re-build network

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Save the network image into a file

Choose image format:

Resolution (DPI):

Save